Exploring the optimal dose of sarmentosin required to reduce MAO-B enzyme activity in healthy adults.

In several previous clinical studies, we have demonstrated the benefits of blackcurrant consumption on mental wellness, including cognitive performance and mood.

Monoamine oxidase-B (MAO-B) enzymes break down important chemicals in the brain, such as dopamine, which plays a crucial role in mood and mental performance. This enzyme is found in the brain, liver, and blood platelets.

Our research has shown that consuming blackcurrants can significantly reduce MAO-B activity in platelets for up to eight hours. This reduction is believed to be a key factor in blackcurrants’ potential to support mental wellbeing.

Recent studies conducted by Plant & Food Research and Callaghan Innovation have identified sarmentosin as the compound in blackcurrants that effectively reduces the activity of MAO-B in platelets.

In this study, we were seeking to understand the optimal dose of sarmentosin required to reduce MAO-B enzyme activity in healthy adults.

The clinical study has now finished; we are no longer seeking volunteers.

This study was approved by the Health & Disabilities Ethics Committees. Ethics reference number 2025 EXP 22591