Blackcurrant sarmentosin research study
Blackcurrant sarmentosin research study
Blackcurrant sarmentosin research study
Exploring the optimal dose of sarmentosin required to reduce MAO-B enzyme activity in healthy adults.
In several previous clinical studies, we have demonstrated the benefits of blackcurrant consumption on mental wellness, including cognitive performance and mood.
Monoamine oxidase-B (MAO-B) enzymes break down important chemicals in the brain, such as dopamine, which plays a crucial role in mood and mental performance. This enzyme is found in the brain, liver, and blood platelets.
Our research has shown that consuming blackcurrants can significantly reduce MAO-B activity in platelets for up to eight hours. This reduction is believed to be a key factor in blackcurrants’ potential to support mental wellbeing.
Recent studies conducted by Plant & Food Research and Callaghan Innovation have identified sarmentosin as the compound in blackcurrants that effectively reduces the activity of MAO-B in platelets.
In this study, we seek to understand the optimal dose of sarmentosin required to reduce MAO-B enzyme activity in healthy adults.
Our Plant & Food Research team are looking for participants to take part in our study:
Healthy adults aged 18 - 50 years
Have a BMI ≤ 40 kg/m^2
Able to travel to Plant & Food Research, Palmerston North
No hypersensitivity to blackcurrants
Non-smokers/vape users
Generally healthy with no long-term illness like cancer or diabetes
Not taking medication for mental health or mood disorders.
Eligible volunteers will attend up to 10 visits to Plant & Food Research, Palmerston North. During the first visit, participants will receive a 250 mL placebo drink. In each subsequent visit, they will receive a drink containing varying doses of sarmentosin. Participants will also provide blood samples and complete mood questionnaires. The dosage of sarmentosin used in this study is equal to or lower than that found in commercially available blackcurrant drinks. The placebo drink will contain blackcurrant flavouring, food colouring and water.
Participants will receive up to $370 in supermarket vouchers as a thank you for completing all trial days and subsequent follow-up visits.
To join this study or for more information contact the trial team at Plant & Food Research on PN.Clinical@plantandfood.co.nz
This study was approved by the Health & Disabilities Ethics Committees. Ethics reference number 2025 EXP 22591